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(11)

EP 1 332 146 A2

(12)

(88) Date of publication A3: 15.08.2002 (43) Date of publication: 06.08.2003 Bulletin 2003/32 (21) Application number: 01978721.7 (22) Date of filing: 23.10.2001

(51) International Patent Classification (IPC)7: C07D 487/10, A61K 31/527, A61P 29/00, A61P 35/00, C07D 471/10 // (C07D487/10, 239:00), C07D209:00,(C07D471/10, 239:00), C07D221:00 (86) International application number: PCT/IB0101/986 (87) International publication number: WO 0203/4753 (02.05.2002 Gazette 2002/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.10.2000 US 243389 P (71) Applicant: Pfizer Products Inc. Groton,Connecticut 06340 (US)

(72) Inventors: BRONK, Brian, Scott,Pfizer Global Res. a. Devel. Groton, CT 06340 (US) NOE, Mark, Carl,Pfizer Global Res. a. Devel. Groton, CT 06340 (US) WYTHES, Martin, James,Pfizer Global Res. a. Devel Groton, CT 06340 (US) (74) Representative: Hirsch, Denise Marie et al Pfizer Global Research and DevelopmentFresnes Laboratories3-9, rue de la LogeB.P. 100 94265 Fresnes Cedex 94265 Fresnes Cedex (FR)