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(11)

EP 1 333 860 A1

(12)

(43) Date of publication: 13.08.2003 Bulletin 2003/33 (21) Application number: 01979303.3 (22) Date of filing: 28.09.2001

(51) International Patent Classification (IPC)7: A61K 39/395, A61K 39/40, G01N 33/53 (86) International application number: PCT/US0130/312 (87) International publication number: WO 0202/6257 (04.04.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.09.2000 US 237082 P (71) Applicant: Yale University New Haven, CT 06520 (US)	(72) Inventors: HOSTETTER, Margaret, K. Milford, CT 06460 (US) DEVORE-CARTER, Denise Gilford, CT 06437 (US) (74) Representative: Cripps, Joanna Elizabeth et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)