(19)

(11)

EP 1 334 112 A2

(12)

(88) Date of publication A3: 21.11.2002 (43) Date of publication: 13.08.2003 Bulletin 2003/33 (21) Application number: 01989984.8 (22) Date of filing: 26.10.2001

(51) International Patent Classification (IPC)7: C07H 21/04, C12P 21/06, G01N 33/53, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US0147/027 (87) International publication number: WO 0203/6076 (10.05.2002 Gazette 2002/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 31.10.2000 US 244700 P (71) Applicants: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US) BANYU PHARMACEUTICAL CO., LTD. Chuo-ku,Tokyo 103-8416 (JP)	(72) Inventors: TAN, Carina Rahway, NJ 07065-0907 (US) NOSSOUGHI, Margarita Rahway, NJ 07065-0907 (US) TOKITA, Shigeru Chuo-ku, Tokyo 103-8416 (JP) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)