(19)
(11) EP 1 334 196 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.09.2009 Bulletin 2009/36

(45) Mention of the grant of the patent:
15.04.2009 Bulletin 2009/16

(21) Application number: 01993615.2

(22) Date of filing: 06.11.2001
(51) International Patent Classification (IPC): 
C12N 15/31(2006.01)
C07K 16/12(2006.01)
 C07K 14/315(2006.01)
A61K 38/16(2006.01)
(86) International application number:
PCT/NL2001/000805
(87) International publication number:
WO 2002/038597 (16.05.2002 Gazette 2002/20)

(54)

GENOMIC FRAGMENT OF STREPTOCOCCUS SUIS AND CLINICAL USES THEREOF

FRAGMENT AUS DEM GENOM VON STREPTOCOCCUS SUIS UND SEINE KLINISCHE VERWENDUNGEN

FRAGMENT DU GENOME DE STREPTOCOQUE SUIS ET UTILISATIONS CLINIQUES

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 09.11.2000 EP 00203947

(43) Date of publication of application:
13.08.2003 Bulletin 2003/33

(73) Proprietor: Stichting Dienst Landbouwkundig Onderzoek
6701 BH Wageningen (NL)

(72) Inventor:
  • SMITH, Hilda, Elizabeth
    NL-8241 AG Lelystad (NL)

(74) Representative: Prins, Adrianus Willem et al
Vereenigde P.O.Box 87930
2508 DH Den Haag
2508 DH Den Haag (NL)


(56) References cited: : 
WO-A-00/05378
 US-A- 5 610 011
   
  • SMITH HILDE E ET AL: "Selection of virulence-associated determinants of Streptococcus suis serotype 2 by in vivo complementation." INFECTION AND IMMUNITY, vol. 69, no. 3, March 2001 (2001-03), pages 1961-1966, XP002199921 ISSN: 0019-9567
  • SMITH H.E. ET AL: "Identification and characterization of the cps locus of Streptococcus suis serotype 2: The capsule protects against phagocytosis and is an important virulence factor." INFECTION AND IMMUNITY, (1999) 67/4 (1750-1756)., XP002126886 cited in the application
  • SMITH, H. E. DE ET AL: "The cps locus of Streptococcus suis serotype 2: genetic determinant for the synthesis of sialic acid" MICROBIAL PATHOGENESIS, (2000) VOL. 29, NO. 2, PP. 127-134. 28 REF. ISSN: 0882-4010, XP000991174 Department of Bacteriology, Institute for Animal Science and Health, P.O. Box 65, 8200 AB Lelystad, Netherlands.
  • BUSQUE P. ET AL: "Immunization of pigs against Streptococcus suis serotype 2 infection using a live avirulent strain." CANADIAN JOURNAL OF VETERINARY RESEARCH, (1997) 61/4 (275-279)., XP000991156
  • SMITH H.E. ET AL: "Repeats in an extracellular protein of weakly pathogenic strains of Streptococcus suis type 2 are absent in pathogenic strains." INFECTION AND IMMUNITY, (1993) 61/8 (3318-3326)., XP000990324
  • SMITH H.E. ET AL: "Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2." INFECTION AND IMMUNITY, (1992) 60/6 (2361-2367)., XP000990323 cited in the application
  • ALLGAIER A. ET AL: "Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits." JOURNAL OF CLINICAL MICROBIOLOGY, (2001) 39/2 (445-453)., XP000992120
  • DATABASE EMBL [Online] STREPT. PNEUMONIAE GENOME FRAG. SEQ ID: 21 23 October 1998 (1998-10-23), NO:21: retrieved from EBI Database accession no. AAV52154
  • DATABASE EMBL [Online] S. PNEUMONIAE FOLC PROTEIN SEQUENCE 16 June 1999 (1999-06-16), retrieved from EBI Database accession no. AAY05071
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).