(19)

(11)

EP 1 335 990 A2

(12)

(88) Date of publication A3: 06.03.2003 (43) Date of publication: 20.08.2003 Bulletin 2003/34 (21) Application number: 01975512.3 (22) Date of filing: 01.10.2001

(51) International Patent Classification (IPC)7: C12Q 1/68, G01N 33/68 (86) International application number: PCT/US0130/334 (87) International publication number: WO 0202/7027 (04.04.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.09.2000 US 236381 P (71) Applicant: THE UNIVERSITY OF ROCHESTER Rochester, NY 14627-0140 (US)	(72) Inventor: ZAUDERER, Maurice Pittsford, NY 14534 (US) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)