(19)
(11) EP 1 337 283 A1

(12)

(43) Date of publication:
27.08.2003 Bulletin 2003/35

(21) Application number: 01932915.0

(22) Date of filing: 02.05.2001
(51) International Patent Classification (IPC)7A61L 15/16
(86) International application number:
PCT/US0114/245
(87) International publication number:
WO 0203/4303 (02.05.2002 Gazette 2002/18)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 27.10.2000 US 697317
27.10.2000 WO PCT/US00/29582

(71) Applicants:
  • Nitromed, Inc.
    Bedford, MA 01730 (US)
  • TRUSTEES OF BOSTON UNIVERSITY
    Boston, MA 02215 (US)

(72) Inventors:
  • LOSCALZO, Joseph
    Dover, MA 02030 (US)
  • VITA, Joseph, A.
    Hingham, MA 02118 (US)
  • LOBERG, Michael, D.
    Boston, MA 02116 (US)
  • WORCEL, Manuel
    Boston, MA 02115 (US)

(74) Representative: Nederlof, Etienne C. 
Octrooibureau Vriesendorp & Gaade,Postbus 266
2501 AW Den Haag
2501 AW Den Haag (NL)

   


(54) METHODS OF TREATING VASCULAR DISEASES CHARACTERIZED BY NITRIC OXIDE INSUFFICIENCY