(19)

(11)

EP 1 337 630 A2

(12)

(88) Date of publication A3: 19.12.2002 (43) Date of publication: 27.08.2003 Bulletin 2003/35 (21) Application number: 01968928.0 (22) Date of filing: 19.09.2001

(51) International Patent Classification (IPC)7: C12N 9/78, C12N 9/96, A61P 35/00, A61K 38/50, C12N 1/20 // C12N1:20, C12R1:35 (86) International application number: PCT/US0129/184 (87) International publication number: WO 0204/4360 (06.06.2002 Gazette 2002/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.11.2000 US 723546 (71) Applicant: Phoenix Pharmacologics, Inc. Exton, PA 19341 (US)	(72) Inventor: CLARK, Mike, A. Lexington, KY 40502 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)