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EP 1 337 634 A2

(12)

(88) Date of publication A3: 13.03.2003 (43) Date of publication: 27.08.2003 Bulletin 2003/35 (21) Application number: 01998630.6 (22) Date of filing: 28.11.2001

(51) International Patent Classification (IPC)7: C12N 15/11, C12N 15/12, C12N 15/62, C07K 14/705, C07K 16/28, A01K 67/027, G01N 33/577, G01N 33/68 (86) International application number: PCT/US0144/859 (87) International publication number: WO 0204/4364 (06.06.2002 Gazette 2002/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.11.2000 US 728420 (71) Applicants: Amgen Inc. Thousand Oaks, CA 91320-1799 (US) AMGEN CANADA INC. Missisauga,Ontario L5N 6J5 (CA)	(72) Inventors: YOSHINAGA, Steven, Kiyoshi Thousand Oaks, CA 91360 (US) MAK, Tak, Wah Toronto, Ontario M5R 1G5 (CA) SHAHINIAN, Arda Markham, Ontario L3S 3P6 (CA) BLADT, Anna, Tafuri Toronto, Ontario M5G 2K2 (CA) SENALDI, Giorgio Thousand Oaks, CA 91362 (US) (74) Representative: Brown, John David  FORRESTER & BOEHMERTPettenkoferstrasse 20-22 80336 München 80336 München (DE)