(19)

(11)

EP 1 337 656 A1

(12)

(43) Date of publication: 27.08.2003 Bulletin 2003/35 (21) Application number: 01980719.7 (22) Date of filing: 06.11.2001

(51) International Patent Classification (IPC)7: C12N 15/861 (86) International application number: PCT/GB0104/916 (87) International publication number: WO 0203/8783 (16.05.2002 Gazette 2002/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.2000 GB 0027501 27.11.2000 US 252927 P (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: WINKLER, Johann Macclesfield,Cheshire SK10 4TG (GB) BUNDELL, Kenneth, Robert Cheshire SK10 4TG (GB) (74) Representative: Hudson, Janette Mary, Dr.  AstraZeneca,Global Intellectual Property 151 85 Sodertalje 151 85 Sodertalje (SE)