(19)

(11)

EP 1 339 851 A2

(12)

(88) Date of publication A3: 14.11.2002 (43) Date of publication: 03.09.2003 Bulletin 2003/36 (21) Application number: 01990521.5 (22) Date of filing: 07.12.2001

(51) International Patent Classification (IPC)7: C12N 15/31 (86) International application number: PCT/EP0114/336 (87) International publication number: WO 0204/6215 (13.06.2002 Gazette 2002/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.12.2000 GB 0030069 13.03.2001 GB 0106158 (71) Applicant: GlaxoSmithKline Biologicals S.A. 1330 Rixensart (BE)	(72) Inventor: THONNARD, Joelle,GlaxoSmithKline B-1330 Rixensart (BE) (74) Representative: Lubienski, Michael John  GlaxoSmithKline,Corporate Intellectual Property,CN925.1,980 Great West Road Brentford,Middlesex TW8 9GS Brentford,Middlesex TW8 9GS (GB)