(19)
(11) EP 1 343 803 A2

(12)

(88) Date of publication A3:
13.03.2003

(43) Date of publication:
17.09.2003 Bulletin 2003/38

(21) Application number: 01968112.1

(22) Date of filing: 24.08.2001
(51) International Patent Classification (IPC)7C07J 1/00, C07J 13/00, C07J 41/00, C07J 9/00, C07J 3/00, C07J 7/00, A61K 31/56, A61P 35/00
(86) International application number:
PCT/US0126/490
(87) International publication number:
WO 0204/2319 (30.05.2002 Gazette 2002/22)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 27.11.2000 US 253385 P
13.12.2000 US 255302 P
23.03.2001 US 278250 P
21.08.2001 US 933894

(71) Applicant: EntreMed, Inc.
Rockville, MD 20850 (US)

(72) Inventors:
  • AGOSTON, Gregory
    Germantown, MD 20874 (US)
  • SHAH, Jamshed, H.
    Brookeville, MD 20833 (US)
  • HUNSUCKER, Kimberly, A.
    Germantown, MD 20874 (US)
  • PRIBLUDA, Victor
    Silver Spring, MD 20902 (US)
  • LAVALLEE, Theresa, M.
    North Potomac, MD 20878 (US)
  • GREEN, Shawn, J.
    Vienna, VA 22182 (US)
  • HERBSTRITT, Christopher, J.
    Rockville, MD 20850 (US)
  • ZHAN, Xiaoguo, H.
    Montgomery Village, MD 20886 (US)
  • TRESTON, Anthony
    Rockville, MD 20851 (US)

(74) Representative: Bannerman, David Gardner et al
Withers & Rogers,Goldings House2 Hays Lane
London SE1 2HW
London SE1 2HW (GB)

   


(54) 2-SUBSTITUTED ESTROGENS AS ANTIANGIOGENIC AGENTS