(19)

(11)

EP 1 343 877 A2

(12)

(88) Date of publication A3: 17.07.2003 (43) Date of publication: 17.09.2003 Bulletin 2003/38 (21) Application number: 01924218.9 (22) Date of filing: 20.03.2001

(51) International Patent Classification (IPC)7: C12N 9/16, C12N 9/22, C12Q 1/68 (86) International application number: PCT/US0108/859 (87) International publication number: WO 0107/0943 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 21.03.2000 US 190813 P (71) Applicant: USB Corporation Cleveland, OH 44128 (US)	(72) Inventors: MOFFETT, Robert, B. Shaker Heights, OH 44122 (US) MULLER-GREVEN, Jeannine Mentor, OH 44060 (US) (74) Representative: Dean, John Paul et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)