(19)

(11)

EP 1 344 057 A2

(12)

(88) Date of publication A3: 23.01.2003 (43) Date of publication: 17.09.2003 Bulletin 2003/38 (21) Application number: 01998129.9 (22) Date of filing: 12.11.2001

(51) International Patent Classification (IPC)7: G01N 33/50, C12N 5/06 (86) International application number: PCT/US0151/190 (87) International publication number: WO 0206/1424 (08.08.2002 Gazette 2002/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.2000 US 710697 (71) Applicant: CHILDREN'S MEDICAL CENTER CORPORATION BostonMassachusetts 02115 (US)	(72) Inventor: ATALA, Anthony Weston, MA 02193 (US) (74) Representative: Kirkham, Nicholas Andrew et al Graham Watt & Co.St. Botolph's House7-9 St. Botolph's Road SevenoaksKent TN13 3AJ SevenoaksKent TN13 3AJ (GB)