(19)

(11)

EP 1 345 622 A2

(12)

(88) Date of publication A3: 03.07.2003 (43) Date of publication: 24.09.2003 Bulletin 2003/39 (21) Application number: 01966602.3 (22) Date of filing: 06.09.2001

(51) International Patent Classification (IPC)7: A61K 39/21, C12N 7/04, C12N 15/49, C12Q 1/70, G01N 33/569 (86) International application number: PCT/US0127/599 (87) International publication number: WO 0202/0049 (14.03.2002 Gazette 2002/11)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.09.2000 US 659029 (71) Applicant: AKZO NOBEL N.V. 6800 LS Arnhem (NL)	(72) Inventors: MONTELARO, Ronald, C. Wexford, PA 15090 (US) CRAIGO, Jodi Pittsburgh, PA 15202 (US) ISSEL, Charles Lexington, KY 40502 (US) PUFFER, Bridget Corning, NY 14830 (US) HENNESSEY, Kristina, J. Parkville, MO 64152 (US) BROWN, Karen, K. Parkville, MO 64152 (US) (74) Representative: Van Gent, Marieke  INTERVET INTERNATIONAL B.V.P.O. Box 31 5830 AA Boxmeer 5830 AA Boxmeer (NL)