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(11)

EP 1 346 049 A2

(12)

(88) Date of publication A3: 21.11.2002 (43) Date of publication: 24.09.2003 Bulletin 2003/39 (21) Application number: 01995077.3 (22) Date of filing: 21.12.2001

(51) International Patent Classification (IPC)7: C12N 15/30, C12N 15/81, C12N 5/10, C07K 14/445, A61K 39/015, G01N 33/68 (86) International application number: PCT/NL0100/934 (87) International publication number: WO 0205/2014 (04.07.2002 Gazette 2002/27)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.12.2000 EP 00204697 (71) Applicant: Stichting Biomedical Primate Research Center 2288 GJ Rijswijk (NL)

(72) Inventors: KOCKEN, Clemens, Hendricus, Martinus NL-2751 DZ Moerkapelle (NL) THOMAS, Alan, William NL-2771 JB Boskoop (NL) BLACKMAN, Michael John Hertfordshire SG5 1SN (GB) WITHERS-MARTINEZ, Chrislaine New BarnetHertfordshire EN5 1NE (GB) HOLDER, Anthony Arthur Mill HillLondon NW7 2DL (GB) (74) Representative: Prins, Adrianus Willem et al Vereenigde,Nieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)