(19)

(11)

EP 1 346 063 A2

(12)

(88) Date of publication A3: 26.06.2003 (43) Date of publication: 24.09.2003 Bulletin 2003/39 (21) Application number: 01956060.6 (22) Date of filing: 30.07.2001

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US0124/036 (87) International publication number: WO 0201/0456 (07.02.2002 Gazette 2002/06)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.07.2000 US 221803 P 17.08.2000 US 226328 P 28.11.2000 US 724898 (71) Applicant: The Institute for Systems Biology Seattle, MA 98105-6099 (US)	(72) Inventors: HOOD, Leroy, E. Seattle, WA 98105 (US) SIEGEL, Andrew, F. Shoreline, WA 98133 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)