(19)

(11)

EP 1 347 745 A2

(12)

(88) Date of publication A3: 23.01.2003 (43) Date of publication: 01.10.2003 Bulletin 2003/40 (21) Application number: 01998311.3 (22) Date of filing: 29.11.2001

(51) International Patent Classification (IPC)7: A61K 9/14, A61K 9/20, A61K 9/48 (86) International application number: PCT/US0144/872 (87) International publication number: WO 0204/3662 (06.06.2002 Gazette 2002/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.11.2000 US 253897 P (71) Applicant: Smithkline Beecham Philadelphia, PA 19103 (US)	(72) Inventor: BENDICH, Adrianne Parsippany, NJ 07054 (US) (74) Representative: Morris, Miriam Elizabeth et al GlaxoSmithKline Corporate Intellectual Property 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)