(19)

(11)

EP 1 349 555 A1

(12)

(43) Date of publication: 08.10.2003 Bulletin 2003/41 (21) Application number: 01986104.6 (22) Date of filing: 04.12.2001

(51) International Patent Classification (IPC)7: A61K 31/70 (86) International application number: PCT/US0146/886 (87) International publication number: WO 0204/5720 (13.06.2002 Gazette 2002/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.12.2000 US 250993 P (71) Applicant: Sloan-Kettering InstituteFor Cancer Research New York,New York 10021 (US)	(72) Inventors: MARTIN, Daniel, S. Pound Ridge, NY 10576 (US) BERTINO, Joseph, R. Branford, CT 06405 (US) KOUTCHER, Jason New Rochelle, NY 10804 (US) (74) Representative: Capasso, Olga et al de Simone & PartnersVia Vincenzo Bellini, 20 00198 Roma 00198 Roma (IT)