(19)

(11)

EP 1 349 571 A2

(12)

(88) Date of publication A3: 19.09.2002 (43) Date of publication: 08.10.2003 Bulletin 2003/41 (21) Application number: 01992588.2 (22) Date of filing: 02.11.2001

(51) International Patent Classification (IPC)7: A61K 39/15, A61K 39/12, A61K 38/00, C12N 15/09, C07H 21/04 (86) International application number: PCT/US0145/255 (87) International publication number: WO 0203/6172 (10.05.2002 Gazette 2002/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.11.2000 US 705621 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)	(72) Inventors: ESTES, Mary, K. Friendswood, TX 77546 (US) BALL, Judith, M. Conroe, TX 77304 (US) TIAN, Peng Congers, NY 10920 (US) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO.,Gray's Inn,14 South Square London WC1R 5JJ London WC1R 5JJ (GB)