(19)
(11) EP 1 351 573 A1

(12)

(43) Date of publication:
15.10.2003 Bulletin 2003/42

(21) Application number: 01994435.4

(22) Date of filing: 20.12.2001
(51) International Patent Classification (IPC)7A01N 57/00, A61K 38/00
(86) International application number:
PCT/US0150/261
(87) International publication number:
WO 0205/6692 (25.07.2002 Gazette 2002/30)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.12.2000 US 258195 P

(71) Applicants:
  • Bristol-Myers Squibb Company
    Princeton, NJ 08543-4000 (US)
  • Oxigene, Inc.
    Watertown, MA 02472 (US)

(72) Inventors:
  • LEE, Francis, Y.
    Yardley, PA 19067 (US)
  • PECK, Ronald
    Cheshire, CT 06410 (US)
  • CHAPLIN, David
    Watlington,Oxfordshire OX9 5SX (GB)
  • PERO, Ronald
    Arlington, Vermont 05250 (US)
  • EDVARDSEN, Klaus
    S-222 22 Lund (SE)

(74) Representative: Schlich, George William et al
Mathys & Squire100 Gray's Inn Road
London WC1X 8AL
London WC1X 8AL (GB)

   


(54) METHODS FOR MODULATING TUMOR GROWTH AND METASTASIS