DERIVATIVES OF THE (3S, 4AR, 6S, 8AR) 6-PHENYLAMINO-1,2,3,4,4A,5,6,7,8,8A-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES - Patent 1351689

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(11)

EP 1 351 689 A2

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(88)	Date of publication A3:
	24.07.2003

(43)	Date of publication:
	15.10.2003 Bulletin 2003/42

(21)	Application number: 01274482.7

(22)	Date of filing: 19.12.2001

(51)	International Patent Classification (IPC)⁷: A61K 31/4725

(86)	International application number:
	PCT/US0145/858

(87)	International publication number:
	WO 0302/4934 (27.03.2003 Gazette 2003/13)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

05.01.2001 EP 01500003

(71)	Applicant: ELI LILLY AND COMPANY
	Indianapolis, Indiana 46285 (US)

(72)	Inventors:
	BLEISCH, Thomas, John Noblesville, IN 46060 (US) CASTANO MANSANET, Ana, Maria,Lilly, S.A. E-28100 Alcobendas (ES) DOMINGUEZ-MANZANARES, Esteban,Lilly, S.A. E-28100 Alcobendas (ES) ESCRIBANO, Ana, Maria,Lilly, S.A. E-28100 Alcobendas (ES) ORNSTEIN, Paul, Leslie Carmel, IN 46032 (US)

(74)	Representative: Kingsbury, Oliver William
	Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)

(54)	DERIVATIVES OF THE (3S, 4AR, 6S, 8AR) 6-PHENYLAMINO-1,2,3,4,4A,5,6,7,8,8A-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES