| (84) |
Designated Contracting States: |
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AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
| (30) |
Priority: |
09.06.2000 US 211331 P
22.06.2000 US 213804 P
|
| (43) |
Date of publication of application: |
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15.10.2003 Bulletin 2003/42 |
| (73) |
Proprietor: The Government of The United States of America, as represented by The Department of
Health and Human Services |
|
Bethesda, MD 20892 (US) |
|
| (72) |
Inventors: |
|
- PASTAN, Ira, H.
Potomac, MD 20854 (US)
- TSUTSUMI, Yasuo
Rockville, MD 20852 (US)
- ONDA, Masanori
Rockville, MD 20852 (US)
- NAGATA, Satoshi
Rockville, MD 20852 (US)
- LEE, Byungkook
Potomac, MD 20854 (US)
- KREITMAN, Robert J.
Potomac, MD 20854 (US)
|
| (74) |
Representative: Thomson, Paul Anthony |
|
Potts, Kerr & Co.
15, Hamilton Square
Birkenhead
Merseyside CH41 6BR
Birkenhead
Merseyside CH41 6BR (GB) |
| (56) |
References cited: :
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- Y. TSUTSUMI ET AL: "Site-specific chemical modification with polyethylene glycol of
recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and
reduces animal toxicity and immunogenicity" PROCEEDINGS OF THE NATIONAL ACADEMY OF
SCIENCES, vol. 97, no. 15, 18 July 2000 (2000-07-18), pages 8548-8553, XP002227760
- R. J. KREITMAN ET AL: "Complete regression of human B-cell lymphoma xenografts in
mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated
by cynomolgus monkeys" INTERNATIONAL JOURNAL OF ACNCER , vol. 81, 1999, pages 148-155,
XP002227761 cited in the application
- R. J. KREITMAN ET AL: "Responses in Refractory Hairy Cell Leukemia to a Recombinant
Immunotoxin" BLOOD, vol. 94, no. 10, 15 November 1999 (1999-11-15), pages 3340-3348,
XP002227762 cited in the application
- MILTON HARRIS J ET AL: "PEGYLATION A NOVEL PROCESS FOR MODIFYING PHARMACOKINETICS"
CLINICAL PHARMACOKINETICS, LEA & FEBIGER, PHILADELPHIA, PA, US, vol. 40, no. 7, 2001,
pages 539-551, XP001106431
- REITER Y ET AL: "IMPROVED BINDING AND ANTITUMOR ACTIVITY OF A RECOMBINANT ANTI-ERBB2IMMUNOTOXIN
BY DISULFIDE STABILIZATION OF THE FV FRAGMENT" JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN
SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 28, 15 July 1994
(1994-07-15), pages 18327-18331, XP000941643 ISSN: 0021-9258 cited in the application
- CHIEN-TSUN KUAN ET AL: "PSEUDOMONAS EXTOXIN A MUTANTS REPLACEMENT OF SURFACE EXPOSED
RESIDUES IN DOMAIN IN WITH CYSTEINERESIDUES THAT CAN BE MODIFIED WITH POLYETHYLENE
GLYCOL IN A SITE-SPECIFIC MANNER" JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY
OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 10, 11 March 1994 (1994-03-11),
pages 7610-7616, XP000563744 ISSN: 0021-9258 cited in the application
- DATABASE MEDLINE [Online] October 1996 (1996-10) TSUTSUMI Y ET AL: "Molecular design
of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified
tumour necrosis factor-alpha affects its anti-tumour potency." Database accession
no. NLM8855980 XP002227763 cited in the application & BRITISH JOURNAL OF CANCER. SCOTLAND
OCT 1996, vol. 74, no. 7, October 1996 (1996-10), pages 1090-1095, ISSN: 0007-0920
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