(19)

(11)

EP 1 351 901 A1

(12)

(43) Date of publication: 15.10.2003 Bulletin 2003/42 (21) Application number: 01990064.6 (22) Date of filing: 13.12.2001

(51) International Patent Classification (IPC)7: C07C 1/207, C07C 1/20, C07C 1/22, C07C 15/46 (86) International application number: PCT/US0147/570 (87) International publication number: WO 0205/5455 (18.07.2002 Gazette 2002/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.12.2000 IL 14027500 (71) Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. Rehovot 76100 (IL)	(72) Inventors: MILSTEIN, David,3 Meonot Brazil 76100 Rehovot (IL) WEISSMAN, Haim 71210 Lod (IL) SONG, XiaoPing Lawrence, KS 66046 (US) (74) Representative: Brown, David Leslie et al Haseltine, Lake & Co,Imperial House,15-19 Kingsway London WC2B 6UD London WC2B 6UD (GB)