(19)

(11)

EP 1 351 930 A2

(12)

(88) Date of publication A3: 31.07.2003 (43) Date of publication: 15.10.2003 Bulletin 2003/42 (21) Application number: 00977056.1 (22) Date of filing: 08.11.2000

(51) International Patent Classification (IPC)7: C07D 201/00, A61K 31/55, C07D 405/14, A61P 19/08, A61P 19/10 (86) International application number: PCT/US0030/682 (87) International publication number: WO 0103/4566 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 10.11.1999 US 164561 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: MARQUIS, Robert, W., Jr. Wayne, PA 19087 (US) VEBER, Daniel, Frank Ambler, PA 19002 (US) (74) Representative: Reeves, Julie Frances  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford,Middlesex TW8 9GS Brentford,Middlesex TW8 9GS (GB)