(19)

(11)

EP 1 353 622 A2

(12)

(88) Date of publication A3: 28.08.2003 (43) Date of publication: 22.10.2003 Bulletin 2003/43 (21) Application number: 01273890.2 (22) Date of filing: 01.11.2001

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US0151/617 (87) International publication number: WO 0208/3063 (24.10.2002 Gazette 2002/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.11.2000 US 245618 P (71) Applicant: Smithkline Beecham Corporation King of Prussia, PA 19406-0939 (US)	(72) Inventors: DAVIS, Charles, B. Collegeville, PA 19426 (US) SHARMA, Amarnath 307591 Singapore (SG) (74) Representative: Thornley, Rachel Mary et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)