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<ep-patent-document id="EP01985432B8W1" file="EP01985432W1B8.xml" lang="de" country="EP" doc-number="1353684" kind="B8" correction-code="W1" date-publ="20110928" status="c" dtd-version="ep-patent-document-v1-4">
<SDOBI lang="de"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI....CY..TR................................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.15 (14 Jul 2008) -  2999001/0</B007EP><B070EP>Die Akte enthält technische Angaben, die nach dem Eingang der Anmeldung eingereicht wurden und die nicht in dieser Patentschrift enthalten sind.</B070EP></eptags></B000><B100><B110>1353684</B110><B120><B121>KORRIGIERTE EUROPÄISCHE PATENTSCHRIFT</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20110928</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>01985432.2</B210><B220><date>20011221</date></B220><B240><B241><date>20030804</date></B241><B242><date>20060125</date></B242></B240><B250>de</B250><B251EP>de</B251EP><B260>de</B260></B200><B300><B310>10100053</B310><B320><date>20010102</date></B320><B330><ctry>DE</ctry></B330></B300><B400><B405><date>20110928</date><bnum>201139</bnum></B405><B430><date>20031022</date><bnum>200343</bnum></B430><B450><date>20110504</date><bnum>201118</bnum></B450><B452EP><date>20101119</date></B452EP><B480><date>20110928</date><bnum>201139</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  38/00        20060101AFI20030902BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  38/03        20060101ALI20030902BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61P   9/10        20060101ALI20030902BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61P  25/00        20060101ALI20030902BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>VERWENDUNG VON DIPEPTIDYLPEPTIDASE IV UND AMINOPEPTIDASE-N INHIBITOREN ZUR BEHANDLUNG VON ISCHÄMIE-INDUZIERTER NEURODEGENERATION</B542><B541>en</B541><B542>USE OF INHIBITORS OF DIPEPTIDYPEPTIDASE IV (EC 3.3.14.5) AND AMINOPEPTIDASE N (EC 3.4.11.2) FOR THE TREATMENT OF NEURODEGENERATION INDUCED BY ISCHAEMIA</B542><B541>fr</B541><B542>UTILISATION D'INHIBITEURS DE LA DIPEPTIDYLPEPTIDASE IV (EC 3.4.14.5) AINSI QUE DE L'AMINOPEPTIDASE N (EC 3.4.11.2) POUR LE TRAITEMENT DE PROCESSUS NEURODEGENERATIFS D'ORIGINE ISCHEMIQUE</B542></B540><B560><B561><text>EP-B- 0 896 538</text></B561><B561><text>EP-B- 1 289 559</text></B561><B561><text>WO-A-98/05333</text></B561><B561><text>WO-A1-01/19866</text></B561><B561><text>WO-A2-2007/127204</text></B561><B561><text>US-A- 5 763 576</text></B561><B561><text>US-A- 2003 148 961</text></B561><B562><text>MARK-KS ET AL.: "Stroke: development, prevention and treatment with peptidase inhibitors" PEPTIDES, Bd. 21, 2000, Seiten 1965-1973, XP002202700</text></B562><B562><text>LOGAN-ME ET AL.: "Bestatin protection against hypoxia induced injury in the guinea-pig heart" JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Bd. 15, Nr. Suppl.4, 11. Juli 1983 (1983-07-11), Seite 32 XP008004193</text></B562><B562><text>AUGUSTYNS K ET AL: "THE UNIQUE PROPERTIES OF DIPEPTIDYL-PEPTIDASE IV (DPP IV/CD26) AND THE THERAPEUTIC POTENTIAL OF DPP IV INHIBITORS" CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, Bd. 6, Nr. 4, 1999, Seiten 311-327, XP000870290 ISSN: 0929-8673</text></B562><B562><text>HALLE J.L.: 'Enzymkinetik: eine Einführung für biochemiker, Mediziner, Biologen, Chemiker und Pharmazeuten', 1987, VEB GUSTAV FISCHER VERLAG</text></B562><B562><text>BARTH A. ET AL: 'Untersuchungen zur Reinigung und Charakterisierung der Dipeptidylaminopeptidase IV' ACTA BIOL MED GER Bd. 32, Nr. 2-3, 1974, Seite 157-174</text></B562><B562><text>SEDO A. ET AL: 'Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities?' BIOCHIM BIOPHYS ACTA Bd. 1550, Nr. 2, 17 Dezember 2001, Seite 107-16</text></B562><B562><text>CHEN T. ET AL: 'Dipeptidyl peptidase IV gene family' ADV EXP MED BIOL. Bd. 524, 2003, Seite 79-86</text></B562><B562><text>KAKUTA H. ET AL: 'Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells' BIOORG MED CHEM LETT. Bd. 13, Nr. 1, 06 Januar 2003, Seite 83-86</text></B562><B562><text>EVANS D.M.: 'Dipeptidyl peptidase IV inhibitors.' IDRUGS Bd. 5, Nr. 6, Juni 2002, Seite 577-585</text></B562><B562><text>STÖCKEL-MASCHEK A. ET AL: 'Potent inhibitors of dipeptidyl peptidase IV and their mechanisms of inhibition' ADV EXP BIOL MED Bd. 477, 2000, Seite 117-123</text></B562><B562><text>WENFANG XU ET AL: 'Progress in the development of aminopeptidase N (APN/CD13) inhibitors' CURR MED CHEM - ANTI CANCER AGENTS Bd. 5, 2005, Seite 281-301</text></B562><B562><text>BAUVOIS B. ET AL: 'Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects' MEDICINAL RESEARCH REVIEWS Bd. 26, Nr. 1, 07 Oktober 2005, Seite 88-130</text></B562><B562><text>ALBISTON A.L.: 'Membrane bound members of the M1 family: more than aminopeptidases' PROTEIN AND PEPTIDES LETTERS Bd. 11, Nr. 5, 2004, Seite 491-500</text></B562><B562><text>Biomol- Product Data Sheet Product: Actinonin</text></B562><B562><text>ABBOTT C.A. ET AL: 'Post-proline-cleaving peptidases having DP IV like enzyme activity. Post-proline peptidases' ADV EXP MED BIOL Bd. 477, 2000, Seite 103-109</text></B562><B562><text>DURINX C. ET AL: 'Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.' EUR J BIOCHEM Bd. 267, Nr. 17, September 2000, Seite 5608-13</text></B562><B562><text>DUKE-COHAN J.S.: 'Attractin: a cub-family protease involved in T cell-monocyte/macrophage interactions.' ADV EXP MED BIOL Bd. 477, 2000, Seite 173-85</text></B562><B562><text>RAWLINGS N.D.; BARRETT A.J.: 'Evolutionary families of metallopeptidases.' METHODS ENZYMOL Bd. 248, 1995, Seite 183-228</text></B562><B562><text>HEO J.H. ET AL: 'Matrix metalloproteinases increase very early during experimental focal cerebral ischemia' J CEREB BLOOD FLOW METAB Bd. 19, Nr. 6, Juni 1999, Seite 624-33</text></B562><B562><text>ROMANIC A.M. ET AL: 'Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size' STROKE Bd. 29, Nr. 5, Mai 1998, Seite 1020-30</text></B562><B562><text>http://www.sigmaaldrich.com/catalog/search /ProductDetail/SIGMA/B8385 B8385 Bestatin hydrochloride Data-sheet</text></B562><B562><text>http://www.sigmaaldrich.com/catalog/search /ProductDetail/SIGMA/A1276 A1276 Amastatin hydrochloride hydrate - Data-sheet</text></B562><B562><text>http://www.brenda-enzymes.info/ Inhibition profiles for inhibitors: Actinonin, Bestatin, Amastatin</text></B562></B560></B500><B700><B720><B721><snm>ANSORGE, Siegfried</snm><adr><str>Am Sportplatz 17</str><city>39291 Hohenwarte</city><ctry>DE</ctry></adr></B721><B721><snm>LENDECKEL, Uwe;
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