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(11)

EP 1 353 907 A2

(12)

(88) Date of publication A3: 13.03.2003 (43) Date of publication: 22.10.2003 Bulletin 2003/43 (21) Application number: 02731078.8 (22) Date of filing: 22.01.2002

(51) International Patent Classification (IPC)7: C07D 213/38, C07D 333/32, C07C 217/84, C07C 217/88, A61K 31/44, A61K 31/36, C07D 215/12, C07D 333/16, C07D 213/73, C07D 405/12, A61P 9/00, A61P 25/24, A61P 11/00 (86) International application number: PCT/US0201/508 (87) International publication number: WO 0207/4726 (26.09.2002 Gazette 2002/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.01.2001 US 262651 P 08.02.2001 US 267196 P 19.07.2001 US 306140 P (71) Applicant: Memory Pharmaceutical Corporation Montvale,New Jersey 07645 (US)

(72) Inventors: HOPPER, Allen Glen Rock, NJ 07452 (US) SCHUMACHER, Richard, A. Monroe, NY 10950 (US) TEHIM, Ashok Ridgewood, NJ 07450 (US) DE VIVO, Michael New York, NY 10024 (US) BRUBAKER, William, Frederick, Jr. Cheshire, CT 06410 (US) LIU, Ruiping Huntington, NY 11743 (US) HESS, Hans-Jürgen, Ernst Old Lyme, CT 06371 (US) UNTERBECK, Axel Madison, CT 06433-0662 (US) (74) Representative: Giraud, Françoise  Cabinet Beau de Loménie158, rue de l'Université 75340 Paris Cedex 07 75340 Paris Cedex 07 (FR)