(19)
(11) EP 1 354 034 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.06.2008 Bulletin 2008/25

(45) Mention of the grant of the patent:
14.11.2007 Bulletin 2007/46

(21) Application number: 01987182.1

(22) Date of filing: 30.11.2001
(51) International Patent Classification (IPC): 
C12N 15/00(2006.01)
C12N 5/06(2006.01)
C12N 5/20(2006.01)
 A01K 67/027(2006.01)
C07K 16/00(2006.01)
(86) International application number:
PCT/US2001/045293
(87) International publication number:
WO 2002/043478 (06.06.2002 Gazette 2002/23)

(54)

TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES

TRANSCHROMOSOMALE TRANSGEN-NAGETIERE ZUR HERSTELLUNG VON HUMÄNEN ANTIKÖRPERN

RONGEURS TRANSGENIQUES ET TRANSCHROMOSOMIQUES POUR LA FABRICATION D'ANTICORPS HUMAINS

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 30.11.2000 US 250340 P

(43) Date of publication of application:
22.10.2003 Bulletin 2003/43

(60) Divisional application:
07021977.9 / 1916303

(73) Proprietors:
  • MEDAREX, INC.
    Milpitas, CA 95035 (US)
  • Kirin Pharma Kabushiki Kaisha
    Shibuya-ku Tokyo (JP)

(72) Inventors:
  • TOMIZUKA, Kazuma
    Takasaki-shi, Gunma 370-0849 (JP)
  • ISHIDA, Isao
    Isehara, Kanagawa 259-1136 (JP)
  • LONBERG, Nils
    Woodside, CA 94062 (US)
  • HALK, Ed
    Sunnyvale, CA 94087 (US)

(74) Representative: Taylor, Anne Janette et al
Hepworth Lawrence Bryer & Bizley Merlin House, Falconry Court Baker's Lane
Epping, Essex CM16 5DQ
Epping, Essex CM16 5DQ (GB)


(56) References cited: : 
US-A- 5 770 429
   
  • TOMIZUKA K ET AL: "DOUBLE TRANS-CHROMOSOMIC MICE: MAINTENANCE F TWO INDIVIDUAL HUMAN CHROMOSOME FRAGMENTS CONTAINING IG HEAVY AND KAPPA LOCI AND EXPRESSION OF FULLY HUMAN ANTIBODIES" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 722-727, XP002949329 ISSN: 0027-8424 cited in the application
  • TAKAI T ET AL: "AUGMENTED HUMORAL AND ANAPHYLACTIC RESPONSES IN FCGAMMARII-DEFICIENT MICE" NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 379, 25 January 1996 (1996-01-25), pages 346-349, XP002933124 ISSN: 0028-0836 cited in the application
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).