(19)

(11)

EP 1 354 063 A2

(12)

(88) Date of publication A3: 14.08.2003 (43) Date of publication: 22.10.2003 Bulletin 2003/43 (21) Application number: 01981799.8 (22) Date of filing: 24.10.2001

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US0132/630 (87) International publication number: WO 0203/4947 (02.05.2002 Gazette 2002/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.10.2000 US 242672 P (71) Applicant: Intergen Company Purchase, NY 10577 (US)	(72) Inventor: KHRIPIN, Yuri Gaithersburg, MD 20878 (US) (74) Representative: Cripps, Joanna Elizabeth et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)