(19)
(11) EP 1 355 670 A2

(12)

(88) Date of publication A3:
24.04.2003

(43) Date of publication:
29.10.2003 Bulletin 2003/44

(21) Application number: 01927519.7

(22) Date of filing: 20.04.2001
(51) International Patent Classification (IPC)7: A61K 47/48
(86) International application number:
PCT/CA0100/555
(87) International publication number:
WO 0108/0900 (01.11.2001 Gazette 2001/44)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 20.04.2000 WO PCT/CA00/00451
20.04.2000 US 553639
25.08.2000 US 227949 P

(71) Applicant: University of British Columbia
Vancouver,British Columbia V6T 1Z3 (CA)

(72) Inventors:
  • LAM, Angela, M., I.
    Vancouver, British Columbia V6P 2B5 (CA)
  • PALMER, Lorne, R.
    Vancouver, British Columbia V6J 1W3 (CA)
  • CULLIS, Pieter, R.
    Vancouver, British Columbia V6R 1H4 (CA)

(74) Representative: Manitz, Finsterwald & Partner GbR 
Martin-Greif-Strasse 1
80336 München
80336 München (DE)

   


(54) ENHANCED STABILISED PLASMID-LIPID PARTICLE-MEDIATED TRANSFECTION USING ENDOSOMAL MEMBRANE DESTABILISERS