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(11)

EP 1 355 925 A2

(12)

(88) Date of publication A3: 28.08.2003 (43) Date of publication: 29.10.2003 Bulletin 2003/44 (21) Application number: 01273903.3 (22) Date of filing: 07.12.2001

(51) International Patent Classification (IPC)7: C07K 14/025, A61K 38/17, A61K 39/12 (86) International application number: PCT/NL0100/893 (87) International publication number: WO 0207/0006 (12.09.2002 Gazette 2002/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.12.2000 EP 00204398 31.08.2001 EP 01203298 (71) Applicant: Academisch Ziekenhuis Leiden 2333 ZA Leiden (NL)

(72) Inventors: VAN DER BURG, Sjoerd, Hendrikus NL-2742 BT Waddinxveen (NL) OTTENHOF, Tom, H., M. 2334 KB Oegsgeest (NL) GELUK, Annemieke NL-2481 XA Woubrugge (NL) SCHOENMAEKERS-WELTERS, Maria, Johanna, Philomena NL-2324 LR Leiden (NL) DE JONG, Annemieke, M. NL-1017 LR Amsterdam (NL) OFFRINGA, Rienk NL-2312 SJ Leiden (NL) MELIEF, Cornelis, Johannes, Maria NL-2012 KC Haarlem (NL) TOES, Rene, Everardus, Maria NL-2311 HN Leiden (NL) (74) Representative: van Westenbrugge, Andries et al Nederlandsch OctrooibureauP.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)