(19)

(11)

EP 1 355 937 A2

(12)

(88) Date of publication A3: 04.09.2003 (43) Date of publication: 29.10.2003 Bulletin 2003/44 (21) Application number: 01273806.8 (22) Date of filing: 14.11.2001

(51) International Patent Classification (IPC)7: C07K 14/52, C07K 16/24, A61K 38/19 (86) International application number: PCT/US0143/884 (87) International publication number: WO 0207/9248 (10.10.2002 Gazette 2002/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.11.2000 US 249686 P (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: GAO, Zeren Redmond, WA 98053 (US) SHOEMAKER, Kimberly, E. Bellevue, WA 98006 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)