(19)

(11)

EP 1 356 087 A2

(12)

(88) Date of publication A3: 24.04.2003 (43) Date of publication: 29.10.2003 Bulletin 2003/44 (21) Application number: 01914028.4 (22) Date of filing: 22.03.2001

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/GB0101/267 (87) International publication number: WO 0107/1030 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 22.03.2000 GB 0006960 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)

(72) Inventors: SATSANGI, JackGastro-Enterology Unit EdinburghEH 4 2XU (GB) WELSH, KennethNational Heart & Lung Institute London SW3 6LR (GB) HALDAR, NeilDepartment of Surgery CliftonvillNorthampton N N1 5BD (GB) CHAPMAN, RogerGastro Intestinal Unit HeadingtonOxford OX3 9DU (GB) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)