(19)

(11)

EP 1 356 093 A2

(12)

(88) Date of publication A3: 14.08.2003 (43) Date of publication: 29.10.2003 Bulletin 2003/44 (21) Application number: 01948623.2 (22) Date of filing: 21.06.2001

(51) International Patent Classification (IPC)7: C12Q 1/68, C07K 14/47, C07K 16/30 (86) International application number: PCT/US0119/980 (87) International publication number: WO 0109/8539 (27.12.2001 Gazette 2001/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 21.06.2000 US 215727 P 27.10.2000 US 243976 P (71) Applicants: Hitachi Chemical Co., Ltd. Shinjuku-ku,Tokyo 163-0490 (JP) HITACHI CHEMICAL RESEARCH CENTER, INC. Irvine, CA 92715 (US) Hitachi, Ltd. Chiyoda-ku,Tokyo 101-0062 (JP)	(72) Inventors: MITSUHASHI, Masato Irvine, CA 92714 (US) KAMBARA, Hideki Hachioji-shi, Tokyo 192-0913 (JP) MATSUNAGA, Hiroko Ames, IA 50014 (US) KAWAMURA, Masafumi Shinjuku-ku, Tokyo 161-0032 (JP) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)