(19)

(11)

EP 1 356 285 A2

(12)

(88) Date of publication A3: 28.08.2003 (43) Date of publication: 29.10.2003 Bulletin 2003/44 (21) Application number: 01975003.3 (22) Date of filing: 27.08.2001

(51) International Patent Classification (IPC)7: G01N 33/50, A61K 39/395, G01N 33/68, C12N 15/10, A61K 47/48, C12N 5/04, C07K 14/705, A61P 35/00, C12N 5/06, C07K 16/28, C12N 15/13, C12N 5/08, C07K 19/00, G01N 33/577, C12N 5/10, A01K 67/027, C12N 15/85 (86) International application number: PCT/NL0100/636 (87) International publication number: WO 0201/8948 (07.03.2002 Gazette 2002/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.08.2000 EP 00202991 28.08.2000 US 228429 P (71) Applicant: Crucell Holland B.V. 2333 CN Leiden (NL)	(72) Inventors: LOGTENBERG, Ton NL-3433 CH Nieuwegein (NL) CILENTI, Lucia I-00183 Roma (IT) BLOEM, Andries, Christiaan NL-3971 BL Driebergen (NL) ZWIJSSEN, Renate, Marie, Louise NL-3583 VE Utrecht (NL) (74) Representative: Klein, Bart  Crucell Holland B.V.,Intellectual Property Department,P.O. Box 2048 2301 CA Leiden 2301 CA Leiden (NL)