(19)

(11)

EP 1 357 898 A2

(12)

(88) Date of publication A3: 24.04.2003 (43) Date of publication: 05.11.2003 Bulletin 2003/45 (21) Application number: 02723104.2 (22) Date of filing: 08.02.2002

(51) International Patent Classification (IPC)7: A61K 9/14, A61K 9/16, A01N 33/02 (86) International application number: PCT/US0203/523 (87) International publication number: WO 0206/2299 (15.08.2002 Gazette 2002/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.02.2001 US 267456 P 08.02.2001 US 267457 P (71) Applicant: ANDRX Pharmaceuticals, Inc. Davie, FL 33314 (US)	(72) Inventors: LI, Boyong Davie, FL 33314 (US) CHEN, Chih-Ming Davie, FL 33328 (US) CHENG, Xiu Xiu Davie, FL 33328 (US) NANGIA, Avinash Weston, FL 33327 (US) (74) Representative: Schupfner, Georg U. et al Müller, Schupfner & Gauger,Parkstrasse 1 21244 Buchholz 21244 Buchholz (DE)