(19)

(11)

EP 1 357 914 A2

(12)

(88) Date of publication A3: 24.04.2003 (43) Date of publication: 05.11.2003 Bulletin 2003/45 (21) Application number: 02709285.7 (22) Date of filing: 31.01.2002

(51) International Patent Classification (IPC)7: A61K 31/421, A61K 31/426, A61P 3/04, A61P 3/06, A61P 3/10, A61P 9/00 (86) International application number: PCT/US0203/017 (87) International publication number: WO 0207/0011 (12.09.2002 Gazette 2002/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.02.2001 US 266393 P (71) Applicant: SmithKline Beecham Corporation Philadelphia,Pennsylvania 19102 (US)	(72) Inventor: WILLSON, Timothy Mark Research Triangle Park, NC 27709 (US) (74) Representative: Learoyd, Stephanie Anne et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)