(19)
(11) EP 1 357 938 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
09.09.2009 Bulletin 2009/37

(45) Mention of the grant of the patent:
22.07.2009 Bulletin 2009/30

(21) Application number: 02700219.5

(22) Date of filing: 08.02.2002
(51) International Patent Classification (IPC): 
A61K 39/095(2006.01)
(86) International application number:
PCT/EP2002/001361
(87) International publication number:
WO 2002/062378 (15.08.2002 Gazette 2002/33)

(54)

HYPERBLEBBING BACTERIAL STRAINS AND USE THEREOF FOR PRODUCTION OF VACCINES

"HYPERBLEBBING" BAKTERIELLE STÄMME UND IHRE VERWENDUNG ZUR HERSTELLUNG VON IMPFSTOFFEN

SOUCHES BACTERIENNES "HYPERBLEB" ET LEUR UTILISATION POUR LA PRODUCTION DE VACCINS

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 08.02.2001 GB 0103171

(43) Date of publication of application:
05.11.2003 Bulletin 2003/45

(60) Divisional application:
09165364.2

(73) Proprietor: SmithKline Beecham Biologicals S.A.
1330 Rixensart (BE)

(72) Inventors:
  • BERTHET, Francois-Xavier Jacques
    1330 Rixensart (BE)
  • DENOEL, PHilippe
    1330 Rixensart (BE)
  • NEYT, Cecile Anne
    1330 Rixensart (BE)
  • POOLMAN, Jan
    1330 Rixensart (BE)
  • THONNARD, Joelle
    1330 Rixensart (BE)

(74) Representative: Lubienski, Michael John 
GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road
Brentford, Middlesex TW8 9GS
Brentford, Middlesex TW8 9GS (GB)


(56) References cited: : 
EP-A- 0 011 243
 WO-A-99/59625
   
  • STURGIS JAMES N: "Organisation and evolution of the tol-pal gene cluster." JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 3, no. 1, January 2001 (2001-01), pages 113-122, XP001089625 January, 2001 ISSN: 1464-1801
  • BERNADAC ALAIN ET AL: "Escherichia coli tol-pal mutants form outer membrane vesicles." JOURNAL OF BACTERIOLOGY, vol. 180, no. 18, 1998, pages 4872-4878, XP002208245 ISSN: 0021-9193
  • LLAMAS MARIA A ET AL: "Mutations in each of the Tol genes of Pseudomonas putida reveal that they are critical for maintenance of outer membrane stability." JOURNAL OF BACTERIOLOGY, vol. 182, no. 17, September 2000 (2000-09), pages 4764-4772, XP002208246 ISSN: 0021-9193
  • EILEENE ROUPPE VAN DER VOORT ET AL.: "Specificity of human bactericidal antibodies against PorA P1.7,16 induced with a hexavalent meningococcal outer membrane vesicle vaccine" INFECTION AND IMMUNITY, vol. 64, no. 7, July 1996 (1996-07), pages 2745-2751, XP002221357
  • TETSURO KOGA ET AL.: "Isolation and characterization of the outer membrane from Vibrio parahemolyticus" THE JOURNAL OF GENERAL MICROBIOLOGY, vol. 129 , no. 9, 1983, pages 3185-3196, XP008010130
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).