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EP 1 358 160 A1

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(43) Date of publication: 05.11.2003 Bulletin 2003/45 (21) Application number: 02704321.5 (22) Date of filing: 31.01.2002

(51) International Patent Classification (IPC)7: C07D 213/74, C07D 405/12, C07C 233/78, C07D 213/76, C07D 213/75, C07D 409/12, C07D 241/20, C07D 213/82, C07D 213/81, A61K 31/44, A61K 31/4965, A61P 9/00, A61P 27/00, A61P 25/00 (86) International application number: PCT/US0202/949 (87) International publication number: WO 0206/2761 (15.08.2002 Gazette 2002/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 07.02.2001 US 778684 14.01.2002 US 46465 (71) Applicant: Abbott Laboratories Abbott Park, IL 60064-6050 (US)

(72) Inventors: KORT, Michael, E. Lake Bluff, IL 60044 (US) CARROLL, William, A. Evanston, IL 60201 (US) PEREZ MEDRANO, Arturo Grayslake, IL 60030 (US) DINGES, Jurgen Grayslake, IL 60030 (US) GREGG, Robert, J. Libertyville, IL 60048 (US) BASHA, Fatima, Z. Lake Forest, IL 60045 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)