(19)

(11)

EP 1 358 196 A2

(12)

(88) Date of publication A3: 04.09.2003 (43) Date of publication: 05.11.2003 Bulletin 2003/45 (21) Application number: 01991006.6 (22) Date of filing: 14.12.2001

(51) International Patent Classification (IPC)7: C07H 19/00, C07H 21/02, C07H 21/04, C12N 15/00, G01N 33/00, G01N 33/53 (86) International application number: PCT/US0147/903 (87) International publication number: WO 0205/0300 (27.06.2002 Gazette 2002/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 20.12.2000 US 256800 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)	(72) Inventors: FOLANDER, Kimberly, L. Rahway, NJ 07065-0907 (US) LIU, Yuan Rahway, NJ 07065-0907 (US) MCKENNA, Edward Rahway, NJ 07065-0907 (US) SWANSON, Richard, J. Rahway, NJ 07065-0907 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)