(19)
(11) EP 1 358 199 A2

(12)

(88) Date of publication A3:
22.08.2002

(43) Date of publication:
05.11.2003 Bulletin 2003/45

(21) Application number: 01988188.7

(22) Date of filing: 26.11.2001
(51) International Patent Classification (IPC)7: C07H 21/04, C12Q 1/68, C12N 15/85
(86) International application number:
PCT/US0144/179
(87) International publication number:
WO 0204/4325 (06.06.2002 Gazette 2002/23)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 27.11.2000 US 723379

(71) Applicants:
  • ISIS PHARMACEUTICALS, INC.
    Carlsbad, CA 92008 (US)
  • The Baylor College of Medicine
    Houston, TX 77030 (US)

(72) Inventors:
  • O'MALLEY, BERT, W.
    Houston, TX 77079 (US)
  • BENNETT, C., Frank
    Carlsbad, CA 92008 (US)
  • COWSERT, Lex, M.
    San Mateo, CA 94402 (US)

(74) Representative: Hallybone, Huw George et al
Carpmaels and Ransford,43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) ANTISENSE MODULATION OF SRC-1 EXPRESSION