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(11)

EP 1 358 314 A2

(12)

(88) Date of publication A3: 06.09.2002 (43) Date of publication: 05.11.2003 Bulletin 2003/45 (21) Application number: 01989119.1 (22) Date of filing: 20.11.2001

(51) International Patent Classification (IPC)7: C12M 1/34, C12M 3/00, C12N 1/00, C12Q 1/00, G01N 21/00, G01N 31/00, G01N 33/53, G01N 33/543, G01N 33/559, G01N 33/561 (86) International application number: PCT/US0144/009 (87) International publication number: WO 0204/8674 (20.06.2002 Gazette 2002/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.11.2000 US 718990 04.01.2001 US 753574 25.04.2001 US 286258 P 08.06.2001 US 296475 P 09.07.2001 US 304031 P (71) Applicants: 20/20 Genesystems, Inc. Rockville, MD 20850 (US) The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services,the Nat. Inst. of Health Rockville, MD 20852 (US)

(72) Inventors: KNEZEVIC, Vladimir Gaithersburg, MD 20878 (US) EMMERT-BUCK, Michael, R. Silver Spring, MD 20904 (US) BAIBAKOVA, Galina Bethesda, MD 20817 (US) HARTMANN, Dan-Paul Bethesda, MD 20814 (US) HEWITT, Stephen Potomac, MD 28054 (US) MITCHELL, Capre Denise Waipahu, HI 96797 (US) GARDNER, Kevin Montgomery Village, MD 20886 (US) (74) Representative: Ritscher, Thomas  Ritscher & Partner AGForchstrasse 452/P.O.Box 372 8029 Zürich 8029 Zürich (CH)