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EP 1 359 926 A1

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(43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 01915650.4 (22) Date of filing: 16.02.2001

(51) International Patent Classification (IPC)7: A61K 35/78, A61P 3/10 (86) International application number: PCT/IN0100/019 (87) International publication number: WO 0207/2122 (19.09.2002 Gazette 2002/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicants: Council of Scientific and Industrial Research New Delhi 110 001,Maharashtra (IN) Sree Chitra Tirunal Institutefor Medical Sciences & Technology Kerala State (IN) Kerala Institute for Research, Training and Development Studies of Scheduled Castes & Scheduled Trib Kerala 673 017 (IN)

(72) Inventors: RAO, Janaswamy Madhusudana Kerala 695 019 (IN) SUMATHYKUTTY, Mangattu Achutankunju Kerala 695 019 (IN) NAIR, Gopalan Vijay Kerala 695 019 (IN) DAMODARAN, Alathur Damodaran Kerala 695 019 (IN) RATHINAM, Kodandaraman,Shee Chitra Tirunal Inst. Kerala 695 011 (IN) SIVAKUMAR, Rajagopal,Sree Chitra Tirunal Inst. Kerala 695 011 (IN) DAS, Kottilil Mohan,Sree Chitra Tirunal Inst. Kerala 695 011 (IN) NAIR, Narayanapillai Viswanathan,Kerala Inst. Calicut,Kerala 673 017 (IN) (74) Representative: Portal, Gérard et al Cabinet Beau de Loménie158, rue de l'Université 75340 Paris Cédex 07 75340 Paris Cédex 07 (FR)