(19)

(11)

EP 1 359 930 A2

(12)

(88) Date of publication A3: 28.08.2003 (43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 01946359.5 (22) Date of filing: 13.06.2001

(51) International Patent Classification (IPC)7: A61K 38/00 (86) International application number: PCT/US0119/094 (87) International publication number: WO 0200/0839 (03.01.2002 Gazette 2002/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.06.2000 US 606858 19.04.2001 US 840009 (71) Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94607-5200 (US) UNIVERSITY OF IOWA RESEARCH FOUNDATION Iowa City, IA 52242-5000 (US)	(72) Inventors: LEHRER, Robert, I. Santa Monica, CA 90403-2228 (US) WARING, Alan, J. Irvine, CA 92614 (US) TACK, Brian, F. Iowa City, IA 52246 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)