(19)

(11)

EP 1 359 940 A2

(12)

(88) Date of publication A3: 04.09.2003 (43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 01950826.6 (22) Date of filing: 29.06.2001

(51) International Patent Classification (IPC)7: A61K 45/06, A61K 31/565, A61P 9/00 (86) International application number: PCT/US0121/085 (87) International publication number: WO 0200/3977 (17.01.2002 Gazette 2002/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.07.2000 US 216096 P 06.07.2000 US 216184 P (71) Applicant: Wyeth Madison, New Jersey 07940-0874 (US)	(72) Inventors: JENKINS, Simon, Nicholas Audubon, PA 19403 (US) KOMM, Barry, Samuel Berwyn, PA 19312 (US) MILLER, Christopher, Paul Strafford, PA 19087 (US) (74) Representative: Wileman, David Francis Dr. et al Wyeth Pharmaceuticals,Huntercombe Lane South,Taplow Maidenhead,Berkshire SL6 OPH Maidenhead,Berkshire SL6 OPH (GB)