(19)

(11)

EP 1 360 195 A2

(12)

(88) Date of publication A3: 07.11.2002 (43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 02711872.8 (22) Date of filing: 15.02.2002

(51) International Patent Classification (IPC)7: C07K 14/285, C12N 15/31, C12N 15/63, A61K 39/102, C07K 16/12, A61K 39/40, A61K 48/00, G01N 33/569 (86) International application number: PCT/EP0201/650 (87) International publication number: WO 0206/6503 (29.08.2002 Gazette 2002/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.02.2001 GB 0103866 (71) Applicant: GlaxoSmithKline Biologicals S.A. 1330 Rixensart (BE)	(72) Inventor: THONNARD, Joelle B-1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)