(19)

(11)

EP 1 360 205 A1

(12)

(43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 02714953.3 (22) Date of filing: 15.02.2002

(51) International Patent Classification (IPC)7: C07K 14/78, C07K 5/08, A61P 35/04 (86) International application number: PCT/US0205/211 (87) International publication number: WO 0206/6512 (29.08.2002 Gazette 2002/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 16.02.2001 US 269537 P 14.09.2001 US 322047 P (71) Applicant: E.I. DUPONT DE NEMOURS AND COMPANY Wilmington,Delaware 19898 (US)	(72) Inventors: SCIALDONE, Mark, A. Oxford, PA 19363 (US) MOUSA, Shaker, A. Lincoln University, PA 19352 (US) SHUEY, Steven, W. Landenberg, PA 19350 (US) (74) Representative: Cockerton, Bruce Roger  Carpmaels & Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)