(19)

(11)

EP 1 360 316 A2

(12)

(88) Date of publication A3: 14.08.2003 (43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 02707442.6 (22) Date of filing: 11.01.2002

(51) International Patent Classification (IPC)7: C12Q 1/42 (86) International application number: PCT/US0200/775 (87) International publication number: WO 0205/5731 (18.07.2002 Gazette 2002/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.01.2001 US 261437 P (71) Applicant: Board of Regents, The University of Texas System Austin, TX 78701 (US)	(72) Inventor: RAAD, Issam Houston, TX 77071 (US) (74) Representative: Dehmel, Albrecht, Dr.  Herzogspitalstrasse 11 80331 München 80331 München (DE)