(19)

(11)

EP 1 360 335 A2

(12)

(88) Date of publication A3: 06.03.2003 (43) Date of publication: 12.11.2003 Bulletin 2003/46 (21) Application number: 02728338.1 (22) Date of filing: 08.02.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C12Q 1/02, C12P 19/34, C12N 1/00 (86) International application number: PCT/US0203/987 (87) International publication number: WO 0208/6097 (31.10.2002 Gazette 2002/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.02.2001 US 267636 P (71) Applicant: Elitra Pharmaceuticals, Inc. San Diego, CA 92121 (US)

(72) Inventors: CARR, Grant J. Escondido, CA 92029 (US) XU, Howard H. San Diego, CA 92129 (US) FOULKES, Gordon J. Encinitas, CA 92024 (US) ZAMUDIO, Carlos La Jolla, CA 92037 (US) HASELBECK, Robert San Diego, CA 92115 (US) OHLSEN, Kari L. San Diego, CA 92117 (US) ZYSKIND, Judith W. La Jolla, CA 92037 (US) WALL, Daniel San Diego, CA 92111 (US) TRAWICK, John, D. La Mesa, CA 91942 (US) YAMAMOTO, Robert, T. San Diego, CA 92122 (US) ROEMER, Terry Montreal, Québec H4V 1X4 (CA) JIANG, Bo Montreal, Québec H3W 2E6 (CA) BOONE, Charles Toronto, Ontario M4T 1K9 (CA) BUSSEY, Howard Westmount, Québec H3Z 2N1 (CA) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)