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(11)

EP 1 363 638 A2

(12)

(88) Date of publication A3: 25.09.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 02714918.6 (22) Date of filing: 31.01.2002

(51) International Patent Classification (IPC)7: A61K 31/505, A61K 31/495, A61K 31/50, A61K 31/535, A61K 31/40, A61K 31/47, A61K 31/44, A61K 31/425, A61K 31/42, A61K 31/415, A61P 25/00, C07D 209/02, C07D 209/82, C07D 215/38, C07D 231/56, C07D 239/02, C07D 261/06, C07D 401/00, C07D 403/02, C07D 405/00, C07D 413/00 (86) International application number: PCT/US0204/608 (87) International publication number: WO 0206/0392 (08.08.2002 Gazette 2002/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.01.2001 US 775341 (71) Applicant: Synaptic Pharmaceutical Corporation Paramus, NJ 07652 (US)

(72) Inventors: BLACKBURN, Thomas P. Hoboken, NJ 07030 (US) KONKEL, Michael Garfield, NJ 07026 (US) BOTEJU, Lakmal W. Cedar, NJ 07009 (US) TALISMAN, Ian Jamie New York, NY 10024 (US) WETZEL, John M. Fairlawn, NJ 07410 (US) PACKIARAJAN, Mathivanan Saddle Brook, NJ 07663 (US) CHEN, Heidi Wyckoff, NJ 07481 (US) JIMENEZ, Hermo Hackensack, NJ 07601 (US) LAGU, Bharat Belle Meade, NJ 08502 (US) LIM, Kitae New York, NY 10014 (US) NOBLE, Stewart Wheeling, IL 60090 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)